The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Sep. 20, 2011
Richard A. Flavell, Guilford, CT (US);
Till Strowig, New Haven, CT (US);
Elizabeth Eynon, New Haven, CT (US);
William Philbrick, New Haven, CT (US);
Markus Manz, Zollikon, CH;
Richard A. Flavell, Guilford, CT (US);
Till Strowig, New Haven, CT (US);
Elizabeth Eynon, New Haven, CT (US);
William Philbrick, New Haven, CT (US);
Markus Manz, Zollikon, CH;
Yale University, New Haven, CT (US);
Abstract
The invention relates generally to compositions and methods of using transgenic non-human animals expressing human SIRPα that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human SIRPα transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of the growth and differentiation of hematopoietic and immune cells, for the in vivo assessment of an immune response, for the in vivo evaluation of vaccines and vaccination regimens, for in vivo production and collection of immune mediators, including human antibodies, and for use in testing the effect of agents that modulate hematopoietic and immune cell function.