The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 26, 2016

Filed:

Apr. 20, 2015
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Sarah C. Heilshorn, Mountain View, CA (US);

Widya Mulyasasmita, Mountain View, CA (US);

Lei Cai, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/42 (2006.01); A61K 9/00 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/42 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); C12N 5/0012 (2013.01); C12N 2533/30 (2013.01); C12N 2533/50 (2013.01);
Abstract

A viscoelastic hydrogel based on a protein hetero-assembled with a polymer is provided. The protein cannot self-assemble with itself and the polymer cannot self-assemble with itself. The protein has a first association sequence (1stA) and a first spacer (1stSp). The polymer has a second association sequence (2ndA) and a second spacer (2ndSp). The first association sequence and the second association sequence are physically cross-linked to interact with each other with a 1:1 known and specific stoichiometry to form a three dimensional scaffold. The protein is represented by {1stA(1stSp)}1stA, where x is ≧2, and the polymer is represented by {2ndA(2ndSp)}2ndA, where y≧2.


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