The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2016
Filed:
Nov. 24, 2014
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA (US);
David B. Weiner, Merion, PA (US);
Jian Yan, Wallingford, PA (US);
Bernadette Ferraro, La Jolla, CA (US);
Niranjan Y. Sardesai, Blue Bell, PA (US);
Mathura P. Ramanathan, Ardmore, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inovio Pharmaceuticals, Inc., Plymouth Meeting, PA (US);
Abstract
Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.