The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2016
Filed:
Apr. 09, 2013
Sequenta, Inc., South San Francisco, CA (US);
Thomas Asbury, San Francisco, CA (US);
Victoria Carlton, San Francisco, CA (US);
Malek Faham, Pacifica, CA (US);
Stephen C. Macevicz, Cupertino, CA (US);
Martin Moorhead, San Mateo, CA (US);
Thomas Willis, San Francisco, CA (US);
Jianbiao Zheng, Fremont, CA (US);
ADAPTIVE BIOTECHNOLOGIES CORPORATION, Seattle, WA (US);
Abstract
The invention is directed to methods for detecting and quantifying nucleic acid contamination in a tissue sample of an individual containing T cells and/or B cells, which is used for generating a sequence-based clonotype profile. In one aspect, the invention is implemented by measuring the presence and/or level of an endogenous or exogenous nucleic acid tag by which nucleic acid from an intended individual can be distinguished from that of unintended individuals. Endogenous tags include genetic identity markers, such as short tandem repeats, rare clonotypes or the like, and exogenous tags include sequence tags employed to determine clonotype sequences from sequence reads.