The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2016
Filed:
Dec. 31, 2014
Applicant:
The Ohio State University, Columbus, OH (US);
Inventors:
Carlo M. Croce, Columbus, OH (US);
Nicola Valeri, Columbus, OH (US);
Assignee:
The Ohio State University, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01); A61K 31/513 (2006.01); A61K 31/713 (2006.01); G01N 33/574 (2006.01); A61K 31/7088 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); A61K 31/513 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); C12N 15/113 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57419 (2013.01); C12Q 2600/112 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01);
Abstract
Described herein is the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed herein.