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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9394282 B1

PDFFull Text
Date of Patent:
Jul. 19, 2016

Filed:

Sep. 21, 2012

Pyrazole carboxamides as janus kinase inhibitors

Applicants:

Jason Brubaker, Cambridge, MA (US);

Joshua Close, Franklin, MA (US);

Tony Siu, Brookline, MA (US);

Graham Frank Smith, Sudbury, MA (US);

Luis E. Torres, Norwood, MA (US);

Hyun Chong Woo, Natick, MA (US);

Jonathan R. Young, Southborough, MA (US);

Zhongyong Wei, Beijing, CN;

Feng Shi, Beijing, CN;

Inventors:

Jason Brubaker, Cambridge, MA (US);

Joshua Close, Franklin, MA (US);

Tony Siu, Brookline, MA (US);

Graham Frank Smith, Sudbury, MA (US);

Luis E. Torres, Norwood, MA (US);

Hyun Chong Woo, Natick, MA (US);

Jonathan R. Young, Southborough, MA (US);

Zhongyong Wei, Beijing, CN;

Feng Shi, Beijing, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Patricia A. Shatynski

Catherine D. Fitch

Primary Examiner:

Michael Barker

Assistant Examiner:

Po-Chih Chen

Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 417/14 (2006.01); C07D 405/04 (2006.01); C07D 413/14 (2006.01); C07D 401/14 (2006.01); C07D 405/08 (2006.01); C07D 403/12 (2006.01); C07D 231/38 (2006.01); C07D 401/12 (2006.01); C07D 403/08 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 403/04 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 405/06 (2006.01);
U.S. Cl.
CPC ...
C07D 405/08 (2013.01); C07D 231/38 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/08 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

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