The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2016
Filed:
Jul. 27, 2012
Bin Zhang, Zhejiang, CN;
Xiaowei HU, Zhejiang, CN;
Pucha Yan, Zhejian, CN;
Xianyi Zhang, Zhejian, CN;
Hongjun Gao, Zhejian, CN;
Yuanqiang LI, Zhejiang, CN;
Daqing Che, Zhejiang, CN;
Bin Zhang, Zhejiang, CN;
Xiaowei Hu, Zhejiang, CN;
Pucha Yan, Zhejian, CN;
Xianyi Zhang, Zhejian, CN;
Hongjun Gao, Zhejian, CN;
Yuanqiang Li, Zhejiang, CN;
Daqing Che, Zhejiang, CN;
Zhejiang Jiuzhou Pharmaceutical Co., Ltd., Taizhou, Zhejiang, CN;
Abstract
Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and Ris hydrogen. The formyl group may be a group having the structure shown by the formula I. Ris a protecting group of carboxyl, and Ris 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.