The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2016
Filed:
Dec. 07, 2012
Artur Manuel Cavaco Paulo, Guimarães, PT;
Ana Arminda Lopes Preto DE Almeida, Braga, PT;
Eugénia Sofia Da Costa Nogueira, Pousa, PT;
Andreia Ferreira Castro Gomes, Braga, PT;
Artur Manuel Cavaco Paulo, Guimarães, PT;
Ana Arminda Lopes Preto de Almeida, Braga, PT;
Eugénia Sofia Da Costa Nogueira, Pousa, PT;
Andreia Ferreira Castro Gomes, Braga, PT;
UNIVERSIDADE DO MINHO, Braga, PT;
Abstract
The present invention is the use of conjugated peptide sequences for inclusion in liposomal membranes. The combination can be done with folic acid or with an antibody of folic acid receptor coupled to N-terminal peptide. The presence of these peptides conjugated to liposomal formulations allows the targeting and subsequent release of therapeutic agents and/or imaging agents to cells expressing folic acid receptor. The developed method combines the ability of liposomes in the transport and release of drugs and the specific expression of folic acid receptor on the surface of cell membranes that allow transmembrane transport mediated by specific liposomes. Thus allows the transport of therapeutic agents and/or imaging agents, which are inside the liposome, either hydrophobic or hydrophilic. The therapeutic agents can be either pharmacological compounds (active agents) or siRNAs (small interference RNA) specific to defined target genes.