The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2016
Filed:
Apr. 14, 2014
Applicant:
Quintessence Biosciences, Inc., Madison, WI (US);
Inventors:
Laura E. Strong, Stoughton, WI (US);
Peter A. Leland, Fitchburg, WI (US);
Thomas Burke, Madison, WI (US);
Assignee:
Quintessence Biosciences, Inc., Madison, WI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2006.01); A61K 38/47 (2006.01); A61K 47/48 (2006.01); C12N 9/22 (2006.01); C12N 9/14 (2006.01); C07H 21/04 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/18 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48569 (2013.01); A61K 38/465 (2013.01); A61K 47/4843 (2013.01); C07K 16/18 (2013.01); C07K 16/2803 (2013.01); C07K 16/3061 (2013.01); C12N 9/12 (2013.01);
Abstract
The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells.