The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2016
Filed:
Jun. 18, 2015
Applicant:
Baylor College of Medicine, Houston, TX (US);
Inventor:
Malcolm K. Brenner, Bellaire, TX (US);
Assignee:
BAYLOR COLLEGE OF MEDICINE, Houston, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2015.01); C12N 5/10 (2006.01); A61K 38/52 (2006.01); A61K 35/17 (2015.01); A61K 35/28 (2015.01); A61K 35/545 (2015.01); A61K 39/00 (2006.01); C12N 5/0783 (2010.01); C12N 5/0775 (2010.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/52 (2013.01); A61K 35/17 (2013.01); A61K 35/28 (2013.01); A61K 35/545 (2013.01); A61K 38/4873 (2013.01); A61K 39/001 (2013.01); C12N 5/0636 (2013.01); C12N 5/0663 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2319/00 (2013.01); C12N 2501/48 (2013.01); C12N 2510/00 (2013.01); C12Y 304/22062 (2013.01); C12Y 502/01008 (2013.01);
Abstract
Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by modifying T cells before administration to a patient, so that they may be selectively killed if GvHD develops in the patient.