The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 19, 2016

Filed:

Apr. 11, 2013
Applicant:

University of Saskatchewan, Saskatoon, CA;

Inventors:

Clarence Ronald Geyer, Saskatoon, CA;

Yu Luo, Saskatoon, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/164 (2006.01); A61K 31/357 (2006.01); A61K 31/409 (2006.01); A61K 31/43 (2006.01); A61K 31/496 (2006.01); A61K 31/555 (2006.01); A61K 31/65 (2006.01); A61K 31/7036 (2006.01);
U.S. Cl.
CPC ...
A61K 31/555 (2013.01); A61K 31/164 (2013.01); A61K 31/357 (2013.01); A61K 31/409 (2013.01); A61K 31/43 (2013.01); A61K 31/496 (2013.01); A61K 31/65 (2013.01); A61K 31/7036 (2013.01);
Abstract

Compounds having the general structural formula (I) wherein X can be any element or compound that can form a coordination complex with phthalocyanine and wherein R1; R2, R3 and R4 are independently anionic moieties, or (II) wherein R1; R2, R3 and R4 are independently anionic moieties, are useful in the potentiation of antibiotic activity, and/or in inhibiting or delaying the development of resistance to antibiotics. R1; R2, R3 and R4 may be —S03-. The compounds may be administered to a subject in conjunction with an antibiotic. The antibiotic may be an activator of the SOS response, and may be a DNA gyrase inhibitor or a topoisomerase inhibitor. Compositions and dosage forms comprising the compounds are provided.


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