Determination of z-effective value for set of voxels using ct density image and sparse multi-energy data

Abstract

Z-effective (e.g., atomic number) values are generated for one or more sets of voxels in a CT density image using sparse (measured) multi-energy projection data. Voxels in the CT density image are assigned a starting z-effective value, causing a CT z-effective image to be generated from the CT density image. The accuracy of the assigned z-effective values is tested by forward projecting the CT z-effective image to generate synthetic multi-energy projection data and comparing the synthetic multi-energy projection data to the sparse multi-energy projection data. When the measure of similarity between the synthetic data and the sparse data is low, the z-effective value assigned to one or more voxels is modified until the measure of similarity is above a specified threshold (e.g., with an associated confidence score), at which point the z-effective values substantially reflect the z-effective values that would be obtained using a (more expensive) dual-energy CT imaging modality.