The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2016

Filed:

Sep. 26, 2013
Applicants:

Cook Biotech Incorporated, West Lafayette, IN (US);

Muffin Incorporated, West Lafayette, IN (US);

Inventors:

Niraj Ramachandran, West Lafayette, IN (US);

Frank J. Fischer, Jr., Bloomington, IN (US);

Michael C. Hiles, Indianapolis, IN (US);

Neal E. Fearnot, West Lafayette, IN (US);

Assignee:

Muffin Incorporated, West Lafayette, IN (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/42 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); A61M 25/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/42 (2013.01); G01N 33/5005 (2013.01); G01N 33/5014 (2013.01); G01N 33/566 (2013.01);
Abstract

Described are methods and systems for testing lumens of cannulated delivery components or assemblies thereof that may be used to deliver cells to a patient. Test cells are contacted with walls of the lumens and/or liquids that contact walls of the lumens, potentially over an incubation period. The test cells are then assessed for an effect of the wall contact, or the liquid contact, on at least one and preferably multiple characteristics of the test cells such as innate immune response, metabolic activity, viability, cytotoxic response, and/or motility. Methods and systems as described can be used in the development and/or manufacture of cannulated delivery devices, for example providing specifications for design or process inputs or outputs, design or process validations, and/or device lot approvals. Also described are devices or products produced in accordance with such methods and systems.


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