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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9388394 B1

PDFFull Text
Date of Patent:
Jul. 12, 2016

Filed:

Jan. 25, 2013

Vaccines against clostridium difficile comprising recombinant toxins

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Jon Henry Heinrichs, Doylestown, PA (US);

Jean-Luc Bodmer, Concord, MA (US);

Susan Lynn Secore, Telford, PA (US);

Aaron Rudy Goerke, Danville, CA (US);

Ivette Caro-Aguilar, Schwenksville, PA (US);

Melanie S. Horton, Ambler, PA (US);

Matthew Ryan Miezeiewski, Phoenixville, PA (US);

Julie M. Skinner, Schwenskville, PA (US);

Su Wang, Schwenksville, PA (US);

Jinfu Xie, Haverford, PA (US);

Rachel Flora Xoconostle, Collegeville, PA (US);

Julie K. Zorman, Quakertown, PA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Gloria Fuentes

Henry P. Wu

Primary Examiner:

Albert Navarro

Int. Cl.
CPC ...
C07K 1/00 (2006.01); C12N 9/10 (2006.01); C07K 14/33 (2006.01); A61K 39/08 (2006.01); C12N 9/52 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1051 (2013.01); A61K 39/08 (2013.01); C07K 14/33 (2013.01); C12N 9/1077 (2013.01); C12N 9/52 (2013.01); A61K 38/00 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55577 (2013.01);
Abstract

The present invention relates to recombinanttoxin A (TcdA) and toxin B (TcdB) and binary toxin A (CDTa) proteins comprising specifically defined mutations relative to the native toxin sequence that substantially reduce or eliminate toxicity. The invention also relates to vaccines and immunogenic compositions comprising these recombinant toxins, as well as combinations of these toxins with binary toxin B (CDTb), which are capable of providing protection againstinfection and/or the effects thereof. The invention also relates to methods of inducing an immune response tocomprising administering the vaccines and immunogenic compositions described herein to a patient. The invention also encompasses methods of expressing recombinanttoxin A and toxin B and CDTa mutants and CDTb in recombinant expression systems. In exemplary embodiments, TcdA, TcdB, and CDTa mutant toxins comprising sufficient mutations to substantially reduce or eliminate toxicity are expressed in the baculovirus/insect cell expression system.

Find Patent Forward Citations

Heinrichs, Jon. (2016). Vaccines against clostridium difficile comprising recombinant toxins (U.S. Patent No. 9388394). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9388394

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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