The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2016

Filed:

Dec. 09, 2014
Applicant:

National Tsing Hua University, Hsinchu, TW;

Inventors:

Yu-Chen Hu, Hsinchu, TW;

Shih-Yeh Lin, Hsinchu, TW;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61K 39/00 (2006.01); C12N 9/50 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); C12N 9/506 (2013.01); A61K 39/00 (2013.01); A61K 2039/5258 (2013.01); C12N 2710/14143 (2013.01); C12N 2770/32023 (2013.01); C12N 2770/32062 (2013.01); C12N 2770/32351 (2013.01);
Abstract

A recombinant baculovirus is provided for preparing picornavirus virus-like particles (VLP), wherein Chitinase A (ChiA) and Cathepsin V (v-cath) genes of the recombinant baculovirus are functionally disrupted and the recombinant baculovirus includes a picornavirus capsid protein gene under control of a strong promoter, and includes a protease gene configured for encoding a protease for hydrolyzing the capsid protein under control of a weak promoter. The recombinant baculovirus of the present invention may adopt High Five or Sf-9 cells for manufacturing enterovirus virus-like particles with improved stability and higher yields in comparison with the conventional arts. A method for preparing virus like particles is also herein provided.


Find Patent Forward Citations

Hu, Yu-Chen. (2016). Method for preparing virus-like particle and recombinant baculovirus used therein (U.S. Patent No. 9388390). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9388390

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