The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2016
Filed:
Oct. 03, 2014
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Ira H. Pastan, Potomac, MD (US);
Ronit Mazor, Rockville, MD (US);
Masanori Onda, Rockville, MD (US);
Byungkook Lee, Potomac, MD (US);
Gerhard Niederfellner, Oberhausen, DE;
Sabine Imhof-Jung, Planegg, DE;
Ulrich Brinkmann, Weilheim, DE;
Guy Georges, Habach, DE;
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Hoffman-La Roche Inc., Little Falls, NJ (US);
Abstract
The invention provides aexotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.