IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9388192 B1

PDFFull Text
Date of Patent:
Jul. 12, 2016

Filed:

Dec. 20, 2013

Benzimidazole derivatives as kinase inhibitors

Applicant:

Selvita SA, Kraków, PL;

Inventors:

Wojciech Czardybon, Mikolów, PL;

Krzysztof Brzózka, Kraków, PL;

Michal Galezowski, Skierniewice, PL;

Renata Windak, Kraków, PL;

Mariusz Milik, Kraków, PL;

Magdalena Zawadzka, Gdansk, PL;

Pawel Guzik, Kraków, PL;

Ewelina Wincza, Wroclaw, PL;

Marta Prokop, Gdynia, PL;

Katarzyna Wiklik, Kraków, PL;

Aleksandra Sabiniarz, Brzeg, PL;

Wieslaw Marek Cholody, Frederick, MD (US);

Raymond Horvath, Montreal, CA;

Tomasz Rzymski, Elblag, PL;

Assignee:

Selvita S.A., Kraków, PL;

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 235/24 (2006.01); C07D 235/30 (2006.01); C07D 235/06 (2006.01); C07D 235/14 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 487/08 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 487/08 (2013.01); C07D 235/06 (2013.01); C07D 235/14 (2013.01); C07D 235/24 (2013.01); C07D 235/30 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01);
Abstract

The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3- and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.

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