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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9388147 B1

PDFFull Text
Date of Patent:
Jul. 12, 2016

Filed:

Feb. 26, 2015

Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis

Applicant:

Receptos, Inc., San Diego, CA (US);

Inventors:

Esther Martinborough, San Diego, CA (US);

Marcus F. Boehm, San Diego, CA (US);

Adam Richard Yeager, La Mesa, CA (US);

Junko Tamiya, Carlsbad, CA (US);

Liming Huang, San Diego, CA (US);

Enugurthi Brahmachary, San Diego, CA (US);

Manisha Moorjani, San Diego, CA (US);

Gregg Alan Timony, San Diego, CA (US);

Jennifer L. Brooks, Encinitas, CA (US);

Robert Peach, San Diego, CA (US);

Fiona Lorraine Scott, San Diego, CA (US);

Michael Allen Hanson, San Marcos, CA (US);

Assignee:

Celgene International II Sárl, Couvet, CH;

Attorney:

Seed IP Law Group PLLC

Primary Examiner:

Yong Chu

Int. Cl.
CPC ...
C07D 271/06 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 413/10 (2006.01); C07D 413/14 (2006.01); A61K 31/4245 (2006.01); A61K 31/427 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07C 245/14 (2006.01); C07C 255/58 (2006.01); C07C 311/13 (2006.01);
U.S. Cl.
CPC ...
C07D 271/06 (2013.01); A61K 31/427 (2013.01); A61K 31/4245 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07C 245/14 (2013.01); C07C 255/58 (2013.01); C07C 311/13 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01);
Abstract

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

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