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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9388127 B1

PDFFull Text
Date of Patent:
Jul. 12, 2016

Filed:

Apr. 17, 2013

Thromboxane receptor antagonists

Applicant:

University College Dublin, National University of Ireland, Dublin, Dublin, IE;

Inventors:

B. Therese Kinsella, Blackrock, IE;

Patrick Guiry, Dublin, IE;

Helen Reid, Dublin, IE;

Barry O'Connor, Dublin, IE;

Assignee:

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN, Belfield, IE;

Attorneys:

Brown Rudnick LLP

Thomas C. Meyers

Primary Examiner:

Wu-Cheng Winston Shen

Assistant Examiner:

Christopher R Stone

Int. Cl.
CPC ...
C07C 311/58 (2006.01); A61K 31/215 (2006.01); A61K 31/64 (2006.01); C07C 311/59 (2006.01); C07D 205/04 (2006.01); C07D 213/53 (2006.01); C07D 213/71 (2006.01); C07D 213/89 (2006.01); C07D 231/12 (2006.01); C07D 261/08 (2006.01); C07D 263/48 (2006.01); C07D 277/34 (2006.01); C07D 295/192 (2006.01); C07D 305/08 (2006.01); C07D 307/52 (2006.01);
U.S. Cl.
CPC ...
C07C 311/58 (2013.01); A61K 31/215 (2013.01); A61K 31/64 (2013.01); C07C 311/59 (2013.01); C07D 205/04 (2013.01); C07D 213/53 (2013.01); C07D 213/71 (2013.01); C07D 213/89 (2013.01); C07D 231/12 (2013.01); C07D 261/08 (2013.01); C07D 263/48 (2013.01); C07D 277/34 (2013.01); C07D 295/192 (2013.01); C07D 305/08 (2013.01); C07D 307/52 (2013.01); C07C 2101/14 (2013.01);
Abstract

The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype.

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