The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2016

Filed:

Aug. 08, 2011
Applicants:

Richard J. Johnson, Centennial, CO (US);

Miguel A. Lanaspa-garcia, Denver, CO (US);

Takuji Ishimoto, Greenwood Village, CO (US);

Inventors:

Richard J. Johnson, Centennial, CO (US);

Miguel A. Lanaspa-Garcia, Denver, CO (US);

Takuji Ishimoto, Greenwood Village, CO (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 38/00 (2006.01); C12N 15/113 (2010.01); A61K 39/395 (2006.01); C07K 16/40 (2006.01); A61K 31/415 (2006.01); A61K 31/7052 (2006.01); A61K 31/427 (2006.01); C12N 9/12 (2006.01); A61K 31/425 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 31/415 (2013.01); A61K 31/427 (2013.01); A61K 31/7052 (2013.01); A61K 38/005 (2013.01); A61K 45/06 (2013.01); C07K 16/40 (2013.01); A61K 39/39533 (2013.01); C12N 9/1205 (2013.01); C12N 15/1137 (2013.01);
Abstract

The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.


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