The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2016

Filed:

Apr. 02, 2013
Applicant:

Annji Pharmaceutical Co., Ltd., Taipei, TW;

Inventors:

Ji-Wang Chern, Taipei, TW;

Chao-Wu Yu, Taipei, TW;

Pei-Teh Chang, Taipei, TW;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); C07D 239/91 (2006.01); C07D 403/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); C07D 239/91 (2013.01); C07D 403/06 (2013.01);
Abstract

Histone deacetylases inhibitors (HDACIs) and compositions comprising the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit are also disclosed. In one aspect, the invention relates to a compound having the structure or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof. In one embodiment of the invention, Ris ethyl; Ris 2-phenylethyl; Ris hydrogen; Ris fluoro; Ris (2E)-3-N-hydroxyamino-3-oxo-propenyl; and Ris hydrogen, or a salt thereof. In another embodiment of the invention, Ris ethyl; Ris 2-phenylethyl; Ris hydrogen; Ris (2E)-3-N-hydroxyamino-3-oxo-propenyl; Ris chloro or fluoro; and Ris hydrogen, or a salt thereof.


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