The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2016
Filed:
Dec. 27, 2013
Development Center for Biotechnology, New Taipei, TW;
National Health Research Institutes, Miaoli County, TW;
Shih-Chong Tsai, New Taipei, TW;
Neng-Yao Shih, Tainan, TW;
Ta-Tung Yuan, New Taipei, TW;
Ko-Jiunn Liu, Tainan, TW;
Shih-Chi Tseng, New Taipei, TW;
Chih-Yung Hu, New Taipei, TW;
Hsin-Yun Wang, New Taipei, TW;
Li-Tzong Chen, Tainan, TW;
Development Center for Biotechnology, New Taipei, TW;
National Health Research Institutes, Miaoli County, TW;
Abstract
The present invention discloses an anti-human alpha-enolase (ENO1) antibody, which can bind the peptides, comprising amino-acid sequence 296FD Q D D W G A W Q K F TA309 (SEQ ID: #9) and/or 326K R I A K A V N EK S336 (SEQ ID: #10) of human ENO1 protein (GenBank: AAH50642.1), has a favorable binding activity (the binding affinity is around 2.19×10-10 mol/L) and a remarkable capability to inhibit the cell invasion and tumor metastasis of a varied of tumors. The recognized peptides and antibody of the invention are useful for diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface ENO1 such as including lung, breast, pancreas, liver, colorectal, prostate cancers and solid tumors.