The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 05, 2016

Filed:

Jul. 03, 2012
Applicants:

Mary Erickson, San Diego, CA (US);

David C. Litzinger, San Diego, CA (US);

Soumitra S. Ghosh, San Diego, CA (US);

Zijian Guo, San Diego, CA (US);

Manoj P. Samant, San Diego, CA (US);

Abhinandini Sharma, San Diego, CA (US);

Lala Mamedova, San Diego, CA (US);

Esther Odile Levy, San Diego, CA (US);

Caroline Ekblad, San Diego, CA (US);

Inventors:

Mary Erickson, San Diego, CA (US);

David C. Litzinger, San Diego, CA (US);

Soumitra S. Ghosh, San Diego, CA (US);

Zijian Guo, San Diego, CA (US);

Manoj P. Samant, San Diego, CA (US);

Abhinandini Sharma, San Diego, CA (US);

Lala Mamedova, San Diego, CA (US);

Esther Odile Levy, San Diego, CA (US);

Caroline Ekblad, San Diego, CA (US);

Assignees:

Amylin Pharmaceuticals, LLC, Wilmington, DE (US);

AstraZeneca Pharmaceuticals LP, Wilmington, DE (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/605 (2006.01); A61K 47/48 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); A61K 47/48338 (2013.01); C12N 15/62 (2013.01); C07K 2319/31 (2013.01); C07K 2319/70 (2013.01);
Abstract

Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced immunogenicity. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, Short Bowel Syndrome, Parkinson's disease, and cardiovascular disease.


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