The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2016
Filed:
Oct. 26, 2012
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Dennis Leung, Rahway, NJ (US);
Todd D. Nelson, Rahway, NJ (US);
Timothy A. Rhodes, Rahway, NJ (US);
Elizabeth Kwong, Kirkland, CA;
Dennis Leung, Scotch Plains, NJ (US);
Todd D. Nelson, Creamridge, NJ (US);
Timothy A. Rhodes, Wayne, PA (US);
Elizabeth Kwong, Kirkland, CA;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 G's to about 100 G's (where 'G' is the force of gravity) for a period sufficient to supply a nano-suspension having a Dof less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.