The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2016
Filed:
Oct. 21, 2013
Bruce N Cronstein, New York, NY (US);
Kathryn J Moore, Westfield, NJ (US);
Aranzazu Mediero-munoz, New York, NY (US);
Bhama Ramkhelawon, New York, NY (US);
Bruce N Cronstein, New York, NY (US);
Kathryn J Moore, Westfield, NJ (US);
Aranzazu Mediero-Munoz, New York, NY (US);
Bhama Ramkhelawon, New York, NY (US);
New York University, New York, NY (US);
Abstract
The invention provides methods and compositions for reducing or inhibiting osteolysis, bone resorption, osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that inhibits the biological activity of an axon guidance protein. The compound or agent my inhibit transcription or translation of or bind to an axon guidance protein, such as, for instance, a netrin like netrin-1. Likewise, the compound or agent may inhibit transcription or translation of or bind to a receptor of an axon guidance protein, such as, for instance, a netrin receptor such as unc5b. In some instances, the compound or agent is an agonist of an adenosine Areceptor. The invention also extends to pharmaceutical compositions comprising such compounds and agents.