The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2016
Filed:
Apr. 10, 2015
Applicant:
AF Chemicals, Llc, San Diego, CA (US);
Inventor:
Michael Kelner, La Jolla, CA (US);
Assignee:
AF CHEMICALS LLC, San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/352 (2006.01); A61K 31/19 (2006.01); A61K 47/48 (2006.01); A61K 31/122 (2006.01);
U.S. Cl.
CPC ...
A61K 31/19 (2013.01); A61K 31/122 (2013.01); A61K 47/48107 (2013.01); A61K 47/48123 (2013.01); A61K 47/48238 (2013.01); A61K 47/48269 (2013.01); A61K 47/48384 (2013.01); A61K 47/48715 (2013.01);
Abstract
In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The medicant moiety can be a toxin including an acylfulvene or a drug moiety. The affinity moiety can be an antibody, a binding protein, a steroid, a lipid, a growth factor, a protein, a peptide or non peptidic. The affinity moiety can be covalently bound to the medicant via a linker. Novel linkers that can be directed to cysteine, arginine or lysine residues based on solution pH allow greater flexibility in preserving and/or generating specific epitopes in the AMC.