The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Nov. 19, 2014
Institut National DE LA Sante ET DE LA Recherche Medicale (Inserm), Paris, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Universite Paris Descartes—paris V, Paris, FR;
Assistance Publique—hopitaux DE Paris, Paris, FR;
Fondation Imagine, Paris, FR;
Olivier Hermine, Paris, FR;
Genevieve Courtois, Paris, FR;
Jean-Benoit Arlet, Paris, FR;
Jean-Antoine Ribeil, Paris, FR;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
Universite Paris Descartes—Paris V, Paris, FR;
Assistance Publique—Hopitaux de Paris, Paris, FR;
Fondation Imagine, Paris, FR;
Abstract
Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.