The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Sep. 08, 2015
Applicant:
Miragen Therapeutics, Inc., Boulder, CO (US);
Inventors:
Rusty L. Montgomery, Boulder, CO (US);
Christina M. Dalby, Boulder, CO (US);
Eva Van Rooij, Utrecht, NL;
Corrie Gallant-Behm, Boulder, CO (US);
Assignee:
miRagen Therapeutics, Inc., Boulder, CO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/0073 (2013.01); A61K 31/713 (2013.01); C12N 2310/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/343 (2013.01); C12N 2310/346 (2013.01); C12N 2320/51 (2013.01);
Abstract
The present invention relates to synthetic oligonucleotide mimetics of miRNAs. In particular, the present invention provides double-stranded, chemically-modified oligonucleotide mimetics of miR-29. Pharmaceutical compositions comprising the mimetics and their use in treating or preventing conditions associated with dysregulation of extracellular matrix genes, such as tissue fibrotic conditions, are also described.