The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 28, 2016

Filed:

Jul. 22, 2015
Applicant:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Akin Akinc, Needham, MA (US);

Alfica Sehgal, Allston, MA (US);

Ivanka Toudjarska, Medford, MA (US);

Donald Foster, Attleboro, MA (US);

Stuart Milstein, Arlington, MA (US);

Brian Bettencourt, Groton, MA (US);

Martin Maier, Belmont, MA (US);

Klaus Charisse, Acton, MA (US);

Satyanarayana Kuchimanchi, Acton, MA (US);

Kallanthottathil G. Rajeev, Wayland, MA (US);

Muthiah Manoharan, Weston, MA (US);

Assignee:

Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/335 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/30 (2013.01);
Abstract

The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.


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