The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Jul. 31, 2014
Gilead Sciences, Inc., Foster City, CA (US);
Kevin S. Currie, North Branford, CT (US);
Zhimin Du, Belmont, CA (US);
Julie Farand, San Mateo, CA (US);
Juan A. Guerrero, Concord, CA (US);
Ashley A. Katana, San Mateo, CA (US);
Darryl Kato, San Francisco, CA (US);
Scott E. Lazerwith, San Francisco, CA (US);
Jiayao Li, Foster City, CA (US);
John O. Link, San Francisco, CA (US);
Nicholas Mai, San Jose, CA (US);
Gregory Notte, San Mateo, CA (US);
Hyung-jung Pyun, Fremont, CA (US);
Michael Sangi, San Mateo, CA (US);
Aaron C. Schmitt, Hamden, CT (US);
Adam J. Schrier, Redwood City, CA (US);
Kirk L. Stevens, Bothell, WA (US);
Chandrasekar Venkataramani, Redwood City, CA (US);
William J. Watkins, Saratoga, CA (US);
Zheng-Yu Yang, Palo Alto, CA (US);
Jeff Zablocki, Los Altos, CA (US);
Sheila Zipfel, San Mateo, CA (US);
Jennifer R. Lo, Branford, CT (US);
Seung H. Lee, Branford, CT (US);
Zhongdong Zhao, Guilford, CT (US);
Jeffrey Kropf, Branford, CT (US);
Jianjun Xu, Madison, CT (US);
Peter Blomgren, North Branford, CT (US);
Scott A. Mitchell, East Haven, CT (US);
JinMing Xiong, Guilford, CT (US);
Jayaraman Chandrasekhar, Trumbull, CT (US);
Gilead Sciences, Inc., Foster City, AR (US);
Abstract
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein X, X, X, R, R, R, R, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.