The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Oct. 10, 2013
Topharman Shanghai Co., Ltd., Pudong, Shanghai, CN;
Shanghai Institute of Materia Medica , Chinese Academy of Sciences, Pudong, Shanghai, CN;
Topharman Shandong Co., Ltd., Weifang, Shandong, CN;
Guan Wang, Shanghai, CN;
Xiangrui Jiang, Shanghai, CN;
Xudong Gong, Shanghai, CN;
Weiming Chen, Shandong, CN;
Fuqiang Zhu, Shanghai, CN;
Rongxia Zhang, Shanghai, CN;
Xianguo Zhao, Shanghai, CN;
TOPHARMAN SHANGHAI CO., LTD., Shanghai, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;
TOPHARMAN SHANDONG CO., LTD., Shandong, CN;
Abstract
This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application.