The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Jan. 17, 2014
Washington University IN St. Louis, St. Louis, MO (US);
Stavros Thomopoulos, St. Louis, MO (US);
Shelly Sakiyama-Elbert, St. Louis, MO (US);
Matthew Silva, St. Louis, MO (US);
Richard Gelberman, St. Louis, MO (US);
Younan Xia, St. Louis, MO (US);
Andrea Schwartz, St. Louis, MO (US);
Jingwei Xie, Omaha, NE (US);
WASHINGTON UNIVERSITY, St. Louis, MO (US);
Abstract
A growth factor delivery scaffold combines a heparin/fibrin-based delivery system (HBDS) with a backbone based on polymer nanofibers for tissue (e.g., tendon and ligament) repair. The scaffold has improved surgical handling properties compared to the gelatinous consistency of the prior art HBDS system and retains the capability for delivering mesenchymal cells and controlling the release of growth factors. One application for the scaffold is mesenchymal stem cell (MSC) therapy for flexor tendon repair. The scaffold can deliver growth factors in a sustained manner, can be implanted for flexor tendon repair, is biocompatible, and is not cytotoxic. The growth factor delivery scaffold may also be used in the surgical repair of an injury to bone, muscle, cartilage, or other tissues.