The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Sep. 10, 2012
Tushar A. Parlikar, Somerville, MA (US);
Gireeja V. Ranade, Berkeley, CA (US);
Thomas Heldt, Cambridge, MA (US);
George C. Verghese, Newton, MA (US);
Tushar A. Parlikar, Somerville, MA (US);
Gireeja V. Ranade, Berkeley, CA (US);
Thomas Heldt, Cambridge, MA (US);
George C. Verghese, Newton, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The methods and systems for estimating cardiac output and total peripheral resistance include observing arterial blood pressure waveforms to determine intra-beat and inter-beat variability in arterial blood pressure and estimating from the variability a time constant for a lumped parameter beat-to-beat averaged Windkessel model of the arterial tree. Uncalibrated cardiac output and uncalibrated total peripheral resistance may then be calculated from the time constant. Calibrated cardiac output and calibrated total peripheral resistance may be computed using calibration data, assuming an arterial compliance that is either constant or dependent on mean arterial blood pressure. The parameters of the arterial compliance may be estimated in a least-squares manner.