The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Jun. 17, 2014
Applicant:
Life Technologies Corporation, Carlsbad, CA (US);
Inventors:
Kyle Gee, Springfield, OR (US);
Vladimir Martin, Eugene, OR (US);
Assignee:
Life Technologies Corporation, Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 23/00 (2006.01); G01N 33/20 (2006.01); C07C 229/18 (2006.01); C07D 221/14 (2006.01); C07D 265/38 (2006.01); C07D 311/82 (2006.01); C09B 5/60 (2006.01); C09B 5/62 (2006.01); C09B 11/06 (2006.01); G01N 33/84 (2006.01); C07D 209/14 (2006.01); C07D 311/90 (2006.01); C07D 413/04 (2006.01);
U.S. Cl.
CPC ...
G01N 33/20 (2013.01); C07C 229/18 (2013.01); C07D 209/14 (2013.01); C07D 221/14 (2013.01); C07D 265/38 (2013.01); C07D 311/82 (2013.01); C07D 311/90 (2013.01); C09B 5/60 (2013.01); C09B 5/62 (2013.01); C09B 11/06 (2013.01); G01N 33/84 (2013.01); C07D 413/04 (2013.01); C09K 2211/1014 (2013.01);
Abstract
The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.