The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Apr. 19, 2011
Haiyong Han, Chandler, AZ (US);
Daniel Von Hoff, Scottsdale, AZ (US);
Caroline Huynh Diep, Minneapolis, MN (US);
Hongwei Yin, Scottsdale, AZ (US);
Haiyong Han, Chandler, AZ (US);
Daniel Von Hoff, Scottsdale, AZ (US);
Caroline Huynh Diep, Minneapolis, MN (US);
Hongwei Yin, Scottsdale, AZ (US);
The Translational Genomics Research Institute, Phoenix, AZ (US);
Abstract
Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating subjects based on identification of the subjects as likely to respond to treatment with BTK inhibitors; therapeutic targets for cancers, particularly cancers with inactivated DPC4 gene or protein; methods of screening of new therapeutic agents using the target; pharmaceutical composition comprising BTK inhibitors, such as PCI-32765 or derivatives thereof, for cancer treatment; and kits that facilitate the performance of the methods are disclosed.