The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Mar. 11, 2010
Applicants:
Daniel A. Vallera, Minneapolis, MN (US);
Jeff Lion, Fresno, CA (US);
Inventors:
Daniel A. Vallera, Minneapolis, MN (US);
Jeff Lion, Fresno, CA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 38/16 (2006.01); A61K 38/19 (2006.01); A61K 47/48 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 38/164 (2013.01); A61K 38/19 (2013.01); A61K 47/48476 (2013.01); A61K 47/48561 (2013.01); A61K 47/48569 (2013.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2319/55 (2013.01);
Abstract
Methods and composition involving genetically engineered targeting conjugates with reversed orientation of VL and VH chains are provided. For example, in certain aspects targeting conjugates comprising VL and VH chains of anti-CD22 and anti-CD19 are described. In a further aspect, the invention provides methods and targeting conjugates comprising therapeutic agents or diagnostic agents for delivery to B cells.