The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Feb. 02, 2015
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
John D. Lambris, Philadelphia, PA (US);
Hongchang Qu, Torrance, CA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 9/00 (2006.01); C07K 7/08 (2006.01); A61K 38/12 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C07K 9/006 (2013.01); A61K 38/12 (2013.01); A61K 47/48023 (2013.01); A61K 47/48246 (2013.01); C07K 7/08 (2013.01); A61K 38/00 (2013.01);
Abstract
Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs having a constrained backbone at position 8 (glycine) and, optionally, specific substitutions for threonine at position 13.