The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Jul. 18, 2011
Applicants:
Ludger A. Wessjohann, Saale, DE;
Orlando Pando Morejon, Saale, DE;
Inventors:
Ludger A. Wessjohann, Saale, DE;
Orlando Pando Morejon, Saale, DE;
Assignee:
Leibniz-Institut Fur Pflanzenbiochemie, Halle (Saale), DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 5/02 (2006.01); C07K 5/078 (2006.01);
U.S. Cl.
CPC ...
C07K 5/02 (2013.01); C07K 5/021 (2013.01); C07K 5/06173 (2013.01);
Abstract
The present invention relates to novel tubulysin compounds (tubulysin analogs) as well as pharmaceutical formulations thereof. The present invention further relates to the use of such compounds for medicinal, agricultural, biotool or cosmetic applications. In particular, the novel tubulysin analogs show a cytostatic effect and can therefore be used for the treatment of proliferative disorders. The tertiary amide moiety of the tubulysin analogs (so-called tubugis) according to the present invention is generated by an Ugi-type reaction.