The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Dec. 27, 2012
Asymchem Laboratories (Tianjin) Co., Ltd, TEDA Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd, TEDA Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd, Teda Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd, Liaoning, CN;
Jilin Asymchem Laboratories Co.,ltd, Jilin, CN;
Hao Hong, Tianjin, CN;
James Gage, Tianjin, CN;
Chaoyong Chen, Tianjin, CN;
Jiangping Lu, Tianjin, CN;
Yan Zhou, Tianjin, CN;
Shuangyong Liu, Tianjin, CN;
Abstract
Disclosed is a method for synthesizing sapropterin dihydrochloride. The present disclosure reduces a synthesis route of the sapropterin dihydrochloride, and resolves a racemate intermediate or an intermediate having a low antimer isomerism value by using a chiral resolving reagent, thereby obtaining an intermediate having a high antimer isomerism value. Raw materials are cheap and readily available, and the cost is significantly reduced, hence providing an effective scheme for mass industrial production of the sapropterin dihydrochloride.