The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Mar. 14, 2012
Vassilios Bavetsias, Sutton, GB;
Butrus Atrash, Sutton, GB;
Sebastien Gaston Andre Naud, Sutton, GB;
Peter William Sheldrake, Sutton, GB;
Julian Blagg, Sutton, GB;
Vassilios Bavetsias, Sutton, GB;
Butrus Atrash, Sutton, GB;
Sebastien Gaston Andre Naud, Sutton, GB;
Peter William Sheldrake, Sutton, GB;
Julian Blagg, Sutton, GB;
CANCER RESEARCH TECHNOLOGY LIMITED, London, GB;
Abstract
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as 'PPA derivatives'), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)