The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Feb. 08, 2008
Hamid Hoveyda, Brussels, BE;
Graeme L. Fraser, Rixensart, BE;
Kamel Benakli, Bluebell, PA (US);
Sophie Beauchemin, Sherbrooke, CA;
Martin Brassard, Sherbrooke, CA;
Eric Marsault, Sherbrooke, CA;
Luc Oullet, Sherbrooke, CA;
Mark L. Peterson, Sherbrooke, CA;
Zhigang Wang, Montreal, CA;
Hamid Hoveyda, Brussels, BE;
Graeme L. Fraser, Rixensart, BE;
Kamel Benakli, Bluebell, PA (US);
Sophie Beauchemin, Sherbrooke, CA;
Martin Brassard, Sherbrooke, CA;
Eric Marsault, Sherbrooke, CA;
Luc Oullet, Sherbrooke, CA;
Mark L. Peterson, Sherbrooke, CA;
Zhigang Wang, Montreal, CA;
Ocera Therapeutics, Inc., Palo Alto, CA (US);
Abstract
The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, bone disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.