The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
May. 29, 2013
Applicant:
Hoffmann-la Roche Inc., Nutley, NJ (US);
Inventors:
David Joseph Bartkovitz, Nutley, NJ (US);
Xin-Jie Chu, Shanghai, CN;
George Kenneth Ehrlich, Bronx, NY (US);
Jin-Jun Liu, Warren Township, NJ (US);
Hanspeter Michel, Bloomfield, NJ (US);
Binh Thanh Vu, North Caldwell, NJ (US);
Chunlin Zhao, Shanghai, CN;
Assignee:
HOFFMANN-LA ROCHE INC., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/16 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07F 9/572 (2006.01); C07H 17/02 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 207/16 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 471/04 (2013.01); C07F 9/5725 (2013.01); C07H 17/02 (2013.01);
Abstract
There are provided compounds of the formula wherein X, Y, Z, R, Rand Rare as described hereinand enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.