The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Aug. 08, 2011
Isao Hara, Kyoto, JP;
Eiichi Ozeki, Kyoto, JP;
Hideo Saji, Kyoto, JP;
Shunsaku Kimura, Hirakata, JP;
Masahiro Ono, Uji, JP;
Takashi Temma, Kyoto, JP;
Isao Hara, Kyoto, JP;
Eiichi Ozeki, Kyoto, JP;
Hideo Saji, Kyoto, JP;
Shunsaku Kimura, Hirakata, JP;
Masahiro Ono, Uji, JP;
Takashi Temma, Kyoto, JP;
SHIMADZU CORPORATION, Kyoto, JP;
KYOTO UNIVERSITY, Kyoto, JP;
Abstract
The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.