The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Jun. 15, 2007
Applicants:
Timothy John Mitchell, Glasgow, GB;
Lea-ann Kirkham, Perth, AU;
Graeme James Cowan, Glasgow, GB;
Gillian Douce, Glasgow, GB;
Inventors:
Timothy John Mitchell, Glasgow, GB;
Lea-Ann Kirkham, Perth, AU;
Graeme James Cowan, Glasgow, GB;
Gillian Douce, Glasgow, GB;
Assignee:
The University Court of the University of Glasgow, Glasgow, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/12 (2006.01); A61K 39/38 (2006.01); A61K 45/00 (2006.01); A61K 39/09 (2006.01);
U.S. Cl.
CPC ...
A61K 39/00 (2013.01); A61K 39/0001 (2013.01); A61K 39/092 (2013.01); A61K 2039/53 (2013.01); A61K 2039/57 (2013.01); A61K 2039/6068 (2013.01);
Abstract
The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.