The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2016
Filed:
Jul. 25, 2012
Le Cong, Cambridge, MA (US);
Ann Marie Egloff, Pittsburgh, PA (US);
Levi A. Garraway, Newton, MA (US);
Jennifer Rubin Grandis, Pittsburgh, PA (US);
Eric S. Lander, Cambridge, MA (US);
Nicholas Stransky, Boston, MA (US);
Aaron D. Tward, Boston, MA (US);
Feng Zhang, Cambridge, MA (US);
Le Cong, Cambridge, MA (US);
Ann Marie Egloff, Pittsburgh, PA (US);
Levi A. Garraway, Newton, MA (US);
Jennifer Rubin Grandis, Pittsburgh, PA (US);
Eric S. Lander, Cambridge, MA (US);
Nicholas Stransky, Boston, MA (US);
Aaron D. Tward, Boston, MA (US);
Feng Zhang, Cambridge, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
University of Pittsburgh-Of The Commonwealth of Higher Education, Pittsburgh, PA (US);
Instituto Carlos Slim de la Salud, A.C., Mexico City, MX;
Abstract
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function.