The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 21, 2016

Filed:

May. 23, 2014
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);

Inventors:

Daria Mochly-Rosen, Menlo Park, CA (US);

Che-Hong Chen, Fremont, CA (US);

Wenjin Yang, Foster City, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/505 (2006.01); A61K 31/422 (2006.01); C07C 233/29 (2006.01); C07D 241/20 (2006.01); C07D 261/14 (2006.01); C07D 317/58 (2006.01); C07D 317/60 (2006.01); C07D 401/12 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 487/04 (2006.01); C07D 491/052 (2006.01); C07D 261/08 (2006.01); A61K 31/4188 (2006.01); A61K 31/5025 (2006.01); A61K 31/519 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); A61K 31/4025 (2006.01); A61K 31/4439 (2006.01); A61K 31/4965 (2006.01); A61K 31/497 (2006.01); C07D 241/18 (2006.01);
U.S. Cl.
CPC ...
A61K 31/422 (2013.01); A61K 31/4025 (2013.01); A61K 31/4188 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/4965 (2013.01); A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07C 233/29 (2013.01); C07D 241/18 (2013.01); C07D 241/20 (2013.01); C07D 261/08 (2013.01); C07D 261/14 (2013.01); C07D 317/58 (2013.01); C07D 317/60 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 487/04 (2013.01); C07D 491/052 (2013.01);
Abstract

The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.


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