The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 2016

Filed:

Jan. 18, 2012
Applicants:

Yona Nadir, Zichron Yaakovv, IL;

Benjamin Brenner, Haifa, IL;

Israel Vlodavsky, Haifa, IL;

Inventors:

Yona Nadir, Zichron Yaakovv, IL;

Benjamin Brenner, Haifa, IL;

Israel Vlodavsky, Haifa, IL;

Assignee:

RAMBAM MED-TECH, Haifa, IL;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/86 (2006.01); C07K 14/81 (2006.01); C07K 14/745 (2006.01); A61K 38/10 (2006.01); A61K 38/08 (2006.01); A61K 38/36 (2006.01); A61K 38/55 (2006.01); A61K 31/727 (2006.01); A61K 45/06 (2006.01); A61K 38/47 (2006.01); A61K 31/5377 (2006.01); A61K 38/51 (2006.01);
U.S. Cl.
CPC ...
G01N 33/86 (2013.01); A61K 31/5377 (2013.01); A61K 31/727 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/36 (2013.01); A61K 38/47 (2013.01); A61K 38/51 (2013.01); A61K 38/55 (2013.01); A61K 45/06 (2013.01); C07K 14/745 (2013.01); C07K 14/8114 (2013.01); C12Y 302/01166 (2013.01);
Abstract

The present invention relates to methods and kits for determining heparanase procoagulant activity in a biological sample. The invention also relates to diagnostic methods for the detection and/or monitoring of a coagulation-related pathologic disorder in a mammalian subject. The invention further relates to compositions comprising heparanase and at least one tissue factor, uses and methods based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions. The invention still further relates to methods for screening a coagulation modulatory compound, methods and uses based thereon in the treatment, amelioration and prevention of coagulation-related pathologic conditions.


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