The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9366628 B1

PDF
Full Text
Expired
Date of Patent:
Jun. 14, 2016

Filed:

Dec. 30, 2014
Applicant:

Leica Biosystems Imaging, Inc., Vista, CA (US);

Inventors:

Gregory Crandall, Vista, CA (US);

Allen Olson, Vista, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01D 18/00 (2006.01); G01N 21/64 (2006.01); G06T 5/00 (2006.01); G06T 5/40 (2006.01); G01N 21/27 (2006.01); G02B 21/36 (2006.01); G06T 7/00 (2006.01); G01J 3/44 (2006.01); G01J 3/02 (2006.01);
U.S. Cl.
CPC ...
G01N 21/64 (2013.01); G01J 3/027 (2013.01); G01J 3/0235 (2013.01); G01J 3/0264 (2013.01); G01J 3/4406 (2013.01); G01N 21/274 (2013.01); G01N 21/6428 (2013.01); G01N 21/6458 (2013.01); G02B 21/365 (2013.01); G06T 5/009 (2013.01); G06T 5/40 (2013.01); G06T 7/0018 (2013.01); G06T 7/0044 (2013.01); G01N 21/278 (2013.01); G01N 21/6452 (2013.01); G01N 2021/6471 (2013.01); G06T 2207/10024 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/10064 (2013.01);
Abstract

Systems and methods for standardizing one or more fluorescence scanning instruments to a reference system by separating the effects of drift and normalization. In an embodiment, a drift image comprising an image of a drift reference slide is captured by a system to be standardized. A drift measurement is calculated using the drift image. A first normalization image comprising an image of a normalization slide is also captured by the system to be standardized. A reference normalization image, also comprising an image of the normalization slide, is captured by a reference system. The first normalization image is compared to the reference normalization image to determine a gamma value and offset value for the system to be standardized.


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