The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2016
Filed:
Sep. 20, 2012
National University of Singapore, Singapore, SG;
Brigham and Women's Hospital, Boston, MA (US);
Li Chai, Boston, MA (US);
Todor Dimitrov, Boston, MA (US);
Daniel Geoffrey Tenen, Singapore, SG;
Kol Jia Yong, Singapore, SG;
Bee Hui Liu, Singapore, SG;
National University of Singapore, Singapore, SG;
Brigham and Women's Hospital, Boston, MA (US);
Abstract
Described are methods of treating a solid tumor which expresses Spalt-Like Transcription Factor 4 (SALL4) and Phosphatase and Tensin Homolog (PTEN) in an individual in need thereof, comprising administering to the individual an effective amount of a composition that inhibits SALL4. In addition, the invention is directed to methods of detecting an aggressive cancer in an individual in need thereof as well as methods of detecting a poor prognosis of a patient with cancer in an individual in need thereof.