The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 2016

Filed:

Mar. 25, 2013
Applicant:

Takeda Pharmaceutical Company Limited, Osaka, JP;

Inventors:

John David Lawson, San Diego, CA (US);

Mark Sabat, San Diego, CA (US);

Christopher Smith, San Diego, CA (US);

Haixia Wang, San Diego, CA (US);

Young K. Chen, San Diego, CA (US);

Toufike Kanouni, San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 413/14 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 407/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); A61K 31/502 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/502 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein R, R, R, R, and Rare defined in the specification. The compounds are inhibitors of Bruton's tyrosine kinase (BTK). This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders or conditions associated with BTK.


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